The bitter principles of gentian root are secoiridoid glycosides amarogentin and gentiopicrin.
2.
This bitter principle was isolated in pure form by Gorter ( 1911 ).
3.
In 1944, Fulton concluded, " Modern medicine considers its sleep producing qualities a superstition, its therapeutic action doubtful or nil . " Another study of the time identified active bitter principles lactucin and lactucopicrin, but noted that these compounds from the fresh latex were unstable and did not remain in commercial preparations of lactucarium.
Meaning
any one of several hundred compounds having a bitter taste; not admitting of chemical classification
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